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  • Title: Structure of influenza haemagglutinin at the pH of membrane fusion.
    Author: Bullough PA, Hughson FM, Skehel JJ, Wiley DC.
    Journal: Nature; 1994 Sep 01; 371(6492):37-43. PubMed ID: 8072525.
    Abstract:
    Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 A to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered.
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