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  • Title: Perinatal primate parathyroid hormone metabolism.
    Author: Fleischman AR, Lerman S, Oakes GK, Epstein MF, Chez RA, Mintz DH.
    Journal: Biol Neonate; 1975; 27(1-2):40-9. PubMed ID: 807268.
    Abstract:
    Near-term fetal and neonatal parathyroid gland function has been studied in the Rhesus monkey. Fetal serum ionized calcium (Ca++) levels are significantly greater than simultaneously obtained maternal levels. Fetal serum parathyroid hormone (PTH) was undetectable both in the basal state and in association with EDTA-induced fetal hypocalcemia. Induced maternal hypocalcemia was associated with increased maternal serum PTH levels and no change in fetal basal serum Ca++ or PTH levels. Only a minimal decrease in simian neonatal serum Ca++ occurred over the first 48 h of life. Normal adult levels of serum PTH were present as early as 6 h of neonatal life. Induced hypocalcemia at 12 h of age resulted in a significant increase in serum PTH levels.
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