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  • Title: immunoperturbation in paraproteinemia.
    Author: Barandum S, Morell A, Skvaril F, Keller H.
    Journal: Birth Defects Orig Artic Ser; 1975; 11(1):95-8. PubMed ID: 807276.
    Abstract:
    The immunoperturbations in paraproteinemias are due predominantly to a disturbance of the B-cell system. The immunologic deficiency is characterized clinically by an increased susceptibility to infections and serologically by a reduction of the nonmyeloma immunoglobulins. In advances cases the capacity to produce specific antibodies is impaired. This may be attributed to a low rate of synthesis or an increased catabolism of normal immunoglobulins.
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