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  • Title: The reaction sites of rotenone and ubiquinone with mitochondrial NADH dehydrogenase.
    Author: Singer TP, Ramsay RR.
    Journal: Biochim Biophys Acta; 1994 Aug 30; 1187(2):198-202. PubMed ID: 8075112.
    Abstract:
    This article summarizes recent studies in the authors' and other laboratories of selective inhibitors acting at the 'rotenone' site and at the Q binding site in the NADH-Q oxidoreductase segment of the respiratory chain. A wide array of inhibitors act at the rotenone site to block electron flux from the enzyme to the Q pool. Using evidence from studies with rotenone, piericidin A, and analogs of the neurotoxic N-methyl-4-phenylpyridinium, we have proposed two binding sites for these inhibitors, both of which must be occupied for complete inhibition of NADH oxidation.
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