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  • Title: Properties of some norvaline-resistant mutants of Bacillus subtilis.
    Author: Holtzclaw WD, Chapman LF.
    Journal: J Gen Microbiol; 1975 Jun; 88(2):289-94. PubMed ID: 807681.
    Abstract:
    DL-Norvaline inhibits growth of wild-type Bacillus subtilis. A number of mutants resistant to growth inhibition by this analogue were isolated and studied. Cross-feeding experiments and paper chromatography of culture supernatants indicated that the mutants excreted leucine and possibly valine and glutamate. Enzymic analysis indicated that the mutants were derepressed for acetohydroxy-acid synthetase and alpha-isopropylmalate synthetase; however, no derepression of threonine deaminase, dihydroxyacid dehydrase or transaminase B was observed.
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