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  • Title: 2-Phenethylimidazole derivatives. Synthesis and antimycotic properties.
    Author: Godefroi EF, Geenen JJ, van Klingeren B, van Wijngaarden LJ.
    Journal: J Med Chem; 1975 May; 18(5):530-3. PubMed ID: 807735.
    Abstract:
    Compounds of type (X = O, NH; Ar and Ar' = phenyl of substituted phenyl; ten examples) were prepared and assayed against miconazole (II,X = O; Ar = Ar' =2,4-Cl2C6H3) as potential antimycotic agents. Optimal activity was noted for I(X = O; Ar = Ar' = 2,4-Cl2C6H3), the direct analog of miconazole. It is about one-tenth as active.
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