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  • Title: Sucralfate suspension as a treatment of recurrent aphthous stomatitis.
    Author: Rattan J, Schneider M, Arber N, Gorsky M, Dayan D.
    Journal: J Intern Med; 1994 Sep; 236(3):341-3. PubMed ID: 8077892.
    Abstract:
    DESIGN: A prospective randomized, double-blind, placebo-controlled, cross-over clinical trial. SETTING: A university hospital. SUBJECTS: Twenty-one patients with symptomatic recurrent aphthous stomatitis (RAS), unresponsive to conventional treatment were enrolled. They were divided into three groups. INTERVENTION: In a cross-over trial, the patients received an oral suspension of sucralfate, an antacid solution or a placebo for 2 years. RESULTS: After 2 years of follow-up, sucralfate was found to be superior to both placebo and antacid (P < 0.001) with regard to duration of pain, reduction of the healing period, response time to first treatment and duration of remission. CONCLUSION: Sucralfate suspension should be added to the armament of treatment modalities of RAS.
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