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  • Title: Activity of BAY y 3118, a novel 4-quinolone, against Brucella melitensis.
    Author: García-Rodríguez JA, García-Sánchez JE, Trujillano-Martín I, García-Sánchez E, García-García MI, Fresnadillo MJ.
    Journal: J Chemother; 1994 Apr; 6(2):102-6. PubMed ID: 8077983.
    Abstract:
    We have tested the in-vitro activities of BAY y 3118, a new chlorofluoroquinolone, ciprofloxacin, sparfloxacin, streptomycin, tetracycline and rifampin against 59 strains of Brucella melitensis. BAY y 3118 (MIC90 0.12 mg/L) was twice as active as sparfloxacin and tetracycline (MIC90 0.25 mg/L). The activity of ciprofloxacin, rifampin and streptomycin (MIC90 0.5, 2, and 8 mg/L, respectively) was, respectively, four-, sixteen-, and more than sixty-fold lower than that of BAY y 3118.
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