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  • Title: Method for simultaneous determination of the distribution of capillary plasma flow and myocyte redox state (NADH-fluorescence) in the hypoperfused myocardium of the anesthetized rat.
    Author: Vetterlein F, Prange M, Tran PN, Schmidt G.
    Journal: Adv Exp Med Biol; 1994; 345():271-3. PubMed ID: 8079718.
    Abstract:
    A method is described which allows to observe the pattern of capillary plasma filling simultaneously with the redox state (NADH-fluorescence) of the myocytes in the hypoperfused myocardium. In anesthetized rats the coronary perfusion pressure was reduced to a defined level, the blood plasma labeled with dye-conjugated albumin and a myocardial biopsy-sampled. Freeze-substitution of histological sections allowed to detect the intravascular plasma label as well as the myocyte NADH-fluorescence on a microscopic level. It was found that areas showing increased cellular NADH-fluorescence did not arise in a distribution congruent with zones of failing capillary plasma flow in the hypoperfused myocardium.
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