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  • Title: Endocrine function in alcoholic Korsakoff's syndrome.
    Author: Emsley RA, Roberts MC, Aalbers C, Taljaard FJ, Kotze TJ.
    Journal: Alcohol Alcohol; 1994 Mar; 29(2):187-91. PubMed ID: 8080600.
    Abstract:
    Hypothalamic-pituitary function was studied by means of several dynamic endocrine tests in 19 patients with alcoholic Korsakoff's syndrome, 17 non-amnesic alcoholics and 21 non-alcoholic controls. The responses of thyroid stimulating hormone, prolactin, follicle stimulating hormone, and luteinizing hormone to a combined thyrotropin releasing hormone and gonadoliberin stimulation test did not differ significantly. For the dexamethasone suppression test, the Korsakoff patients had significantly higher basal serum cortisol and 08:00 hr post-dexamethasone cortisol levels than non-alcoholic controls. These findings raise the possibility that chronically elevated cortisol levels may contribute to cognitive impairment in alcoholic Korsakoff's syndrome.
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