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  • Title: Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy.
    Author: Woodburn KW, Hill JS, Stylli S, Kaye AH, Reiss JA, Phillips DR.
    Journal: Br J Cancer; 1994 Sep; 70(3):398-400. PubMed ID: 8080721.
    Abstract:
    The photonecrotic effectiveness of a morpholinothiolporphyrin derived from haematoporphyrin was measured in an animal model of cerebral glioma. The dose administered was 20 mg kg-1 and the laser dose varied from 0 to 200 J cm-2. The tumour necrosis was at least as good as that of HpD, and this therapeutic response may be attributed to the targeting of specific 'photopotent' subcellular sites.
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