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  • Title: H+/base transport pathways in the cortical collecting duct.
    Author: Emmons C, Kurtz I.
    Journal: Exp Nephrol; 1993; 1(6):325-33. PubMed ID: 8081983.
    Abstract:
    The CCD possesses the unique ability to alter not only the magnitude but also the direction of transepithelial H+/base and Cl- transport during changes in systemic acid-base balance. The single cell transport processes which are responsible for mediating these changes are presently incompletely understood. Functional evidence is emerging that the subdivision of intercalated cells into 2 subtypes is overly simplistic. The complexity of CCD H+/base transport is further demonstrated by the species differences which exist between the rat and rabbit. With the finding of a third CCD intercalated cell subtype (gamma cell), it is expected that future studies will focus on the transport changes which occur in this cell during systemic acid-base disorders.
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