These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Discriminative stimulus effects of combinations of pentobarbital and ethanol in rhesus monkeys.
    Author: Massey BW, Woolverton WL.
    Journal: Drug Alcohol Depend; 1994 Mar; 35(1):37-43. PubMed ID: 8082554.
    Abstract:
    Rhesus monkeys (N = 3) were trained in a 2-lever drug discrimination paradigm to discriminate pentobarbital (PB; 10 mg/kg, i.g., 60 min pre-session) from saline. Lever pressing was maintained under a discrete-trials shock avoidance schedule of reinforcement (30 trials/day, 30-s ITI, FR1). Before test sessions, in which responding on either lever was reinforced, the monkeys were injected with PB and ethanol (EtOH), alone or in combination. Administration of PB alone resulted in a dose-related increase (0-100%) in the percentage of responses emitted on the drug-appropriate lever. The mean ED50 for PB was 7.0 mg/kg (95% C.L. = 6.3-7.7 mg/kg). When administered 60 min pre-session, EtOH engendered a dose-related increase in PB appropriate trials and substituted completely for PB at 3.0 g/kg in two monkeys. In the third monkey, EtOH engendered a maximum of 65% PB-appropriate responding at 1.7 g/kg given 30 min pre-session and predominantly saline-appropriate responding at other pretreatment times. The group ED50 for EtOH at the time of maximum effect was 1.9 g/kg (95% C.L. = 1.4-2.5 g/kg). Administration of 0.3 g/kg EtOH in combination with PB had little or no effect on the PB dose effect function (PB ED50 = 6.7 mg/kg) while 1.0 g/kg EtOH shifted the PB dose-effect function to the left in all monkeys, an average of approximately 3-fold (PB ED50 = 2.1 mg/kg). Isobolographic analysis of the effects of the combination revealed that EtOH and PB were dose additive.
    [Abstract] [Full Text] [Related] [New Search]