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  • Title: PHA-stimulated cellular immune function and T-lymphocyte subsets in major depressive disorders.
    Author: Anesi A, Franciotta D, Di Paolo E, Zardini E, Melzi d'Eril GV, Zerbi F.
    Journal: Funct Neurol; 1994; 9(1):17-22. PubMed ID: 8082849.
    Abstract:
    We measured some immunological parameters in 20 hospitalized patients with major depression and 20 age- and sex-matched healthy controls. Both enumeration of immune cells, including T-lymphocyte subpopulations, and assay of T-cell function were studied. White blood cells were evaluated with an automated cell counter, T-cell subsets with an immunobead technique, and T-cell function with a phytohemagglutinin-induced proliferation in vitro assay. We found that T-lymphocyte responses to the mitogen were significantly lower in depressed patients than in controls. All the other parameters were normal. These findings suggest that functional but not numerical changes in T-lymphocytes characterize major depressive disorders.
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