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  • Title: [A case of congenital protein C deficiency with pulmonary thromboembolism].
    Author: Takeda K, Kumagai H, Hayashi S, Tanio Y, Kawase I, Kishimoto T, Fujiwara M.
    Journal: Nihon Kyobu Shikkan Gakkai Zasshi; 1994 May; 32(5):497-501. PubMed ID: 8084108.
    Abstract:
    A 47-year-old woman, with a history of recurrent venous thrombosis in her lower limbs (1988 and June, 1992), was admitted because of pulmonary thromboembolism in the right middle lung lobe. She was given anti-coagulant therapy with warfarin. The consolidation in the right middle lobe disappeared within two months. Hematological examinations concerning the coagulation and fibrinolytic system showed a significant decrease in both the serum concentration and the activity of protein C, a vitamin K-dependent hepatic protein which acts as an anticoagulant by shutting off fibrin formation and stimulating fibrinolysis. Since a sister of the patient also has a history of venous thrombosis, several members of her family were tested for protein C deficiency. The familial study revealed that her sister and mother had both a decreased concentration and depressed activity of protein C, indicating that this is a case of congenital protein C deficiency. Warfarin therapy has been continued to reduce the prothrombin time to 70% of the normal control level, resulting in no further episodes of thrombosis.
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