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  • Title: [Cryoglobulins in rheumatoid arthritis: exhaustive detection, immunochemical findings and clinical expression].
    Author: Bekavac J, Varas MA, Ardiles A, Aris H, Parra MA, Orellana J, Santa Cruz C, Silva MC.
    Journal: Rev Med Chil; 1994 Feb; 122(2):180-5. PubMed ID: 8085083.
    Abstract:
    Cryoglobulins were measured in 29 patients (24 female, age 53.8 +/- 9.8 years) with rheumatoid arthritis (70% active). The cryoprecipitate was isolated, characterized and quantified. Cryoglobulinemia, always polyclonal or type III, was found in 83% of patients. The most frequent immunochemical isotypes found were IgG and A. Acrocyanosis was found in 50% and Raynaud phenomenon in 32% of patients with cryoglobulinemia. It is concluded that exhaustive detection of cryoglobulinemia in rheumatoid arthritis demonstrated a higher frequency than previously reported an is important for understanding pathogenesis of the disease.
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