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  • Title: [Effects of beta-endorphin on blood pressure and heart rate in rats].
    Author: Xiao Q, Chen QS, Yan ZH, Yang R, Dai YL.
    Journal: Sheng Li Xue Bao; 1994 Feb; 46(1):72-7. PubMed ID: 8085171.
    Abstract:
    The present work was undertake to investigate the mechanism of changes of blood pressure and heart rate induced by beta-endorphin (beta-End) after microinjection into the Nucleus Amygdaloideus Centralis (AC) of anaesthetized rats. The results were as follows: (1) beta-End (100, 250 pg/microliters) injected into AC decreased both blood pressure and heart rate. (2) Both these effects could be antagonized by naloxone and beta-End anti-serum. (3) The effects of beta-End could also be reversed by phentolamine and propranolol. The results showed that the cardiovascular effects on beta-End were mediated by opioid receptors and through the intervention of adrenergic neurons.
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