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  • Title: Circadian rhythms of melatonin, cortisol and prolactin in patients with obsessive-compulsive disorder.
    Author: Monteleone P, Catapano F, Del Buono G, Maj M.
    Journal: Acta Psychiatr Scand; 1994 Jun; 89(6):411-5. PubMed ID: 8085472.
    Abstract:
    Plasma melatonin, cortisol and prolactin (PRL) levels were measured over a 24-h period in 13 drug-free patients with obsessive-compulsive disorder and in matched healthy subjects. The circadian profiles of melatonin and PRL were altered in patients; the circadian rhythm of cortisol was preserved, although at a higher level compared with normal controls. These changes were significantly related to the severity of the obsessive-compulsive symptoms. Further studies need to clarify the state- or trait-dependent character of these abnormalities.
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