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  • Title: Homogentisic acid is the product of MelA, which mediates melanogenesis in the marine bacterium Shewanella colwelliana D.
    Author: Coon SL, Kotob S, Jarvis BB, Wang S, Fuqua WC, Weiner RM.
    Journal: Appl Environ Microbiol; 1994 Aug; 60(8):3006-10. PubMed ID: 8085836.
    Abstract:
    Shewanella colwelliana D is a marine procaryote which produces a diffusible brown pigment that correlates with melA gene expression. Previously, melA had been cloned, sequenced, and expressed in Escherichia coli; however, the reaction product of MelA had not been identified. This report identifies that product as homogentisic acid, provides evidence that the pigment is homogentisic acid-melanin (pyomelanin), and suggests that MelA is p-hydroxyphenylpyruvate hydroxylase. This is the first report of pyomelanin in an obligate marine bacterium.
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