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  • Title: [A stage IIIc ovarian cancer case of pathological CR after combination treatment with carboplatin and cisplatin].
    Author: Onishi Y, Maruyama H, Kume K, Hatae M.
    Journal: Gan To Kagaku Ryoho; 1994 Sep; 21(12):2053-6. PubMed ID: 8085858.
    Abstract:
    Combination carboplatin and cisplatin (JP) is one of the new strategies for increasing dose intensity and total platinum dose in ovarian cancer chemotherapy. We treated a woman age 65, with stage IIIc ovarian cancer. At the first operation, the tumor size was 20 cm and could not be removed because of severe adhesion of intestine. After 4 courses of JP, she underwent second optimal surgery (total hysterectomy, bilateral salpingo-oophorectomy and omentectomy). There were no residual cancer cells microscopically in any specimen. Following 2 additional courses of JP, the patient is alive with no evidence of disease 18 months after the first operation. JP proved to be an efficacious strategy to increase platinum dose intensity for this advanced ovarian cancer.
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