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  • Title: beta-Amyloid protein-induced Alzheimer's disease animal model.
    Author: Nitta A, Itoh A, Hasegawa T, Nabeshima T.
    Journal: Neurosci Lett; 1994 Mar 28; 170(1):63-6. PubMed ID: 8086012.
    Abstract:
    To investigate the toxicity of beta-amyloid protein which consisted of senile plaques of Alzheimer's disease (AD), this was infused into cerebral ventricle for 14 days by using mini-osmotic pump. The performance of the water maze task in beta-amyloid protein-treated rats was impaired. Choline acetyltransferase activity significantly decreased in the frontal cortex and hippocampus. These results suggest that the deposition of beta-amyloid protein in the brain is related to the impairment of learning and cholinergic neuronal degeneration, and that beta-amyloid protein-treated rats could be used as an animal model for AD.
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