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  • Title: Intact mummified bone alkaline phosphatase.
    Author: Weser U, Kaup Y.
    Journal: Biochim Biophys Acta; 1994 Sep 21; 1208(1):186-8. PubMed ID: 8086434.
    Abstract:
    Our knowledge to the mode of conservation of mummified structurally and functionally intact biopolymers is limited. Rib samples of a well-preserved 2300-year old ptolemeic mummy were examined whether or not functionally active Zn2Mg alkaline phosphatase could be detected. A protein of M(r) 170 +/- 20 kDa being close to 200 kDa of the enzyme of fresh bones was successfully isolated. Both a 200 kDa protein and a distinct subunit of 60 kDa were seen in SDS-PAGE electrophoresis which was identical to those of fresh bone alkaline phosphatase. There was a significant enzymic activity of 17 mU/mg protein which could be inhibited in the presence of L-homoarginine and 1,10-phenanthroline.
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