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  • Title: Successful response to alpha-interferon 2b in a refractory IgM autoagglutinin-mediated hemolytic anemia.
    Author: Fest T, de Wazières B, Lamy B, Maskani M, Vuitton D, Dupond JL.
    Journal: Ann Hematol; 1994 Sep; 69(3):147-9. PubMed ID: 8086510.
    Abstract:
    We describe the beneficial effect of recombinant alpha 2b interferon in a woman with an idiopathic and refractory IgM-mediated autoimmune hemolytic anemia due to low-titer, high-thermal-amplitude cold agglutinins. The response was partial but sustained, 2 months after interruption of interferon, with hemoglobin concentrations ranging between 8.5 and 10 g/dl. In the literature, such rarely encountered hemolyzing warm-reacting agglutinins are described as causing severe hemolysis with a frequently fatal clinical outcome.
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