These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Desensitization of c-fos mRNA expression in rat brain following cortical lesions.
    Author: Ivkovic S, Kanazir S, Stojiljkovic M, Rakic L, Ruzdijic S.
    Journal: Mol Cell Neurosci; 1994 Feb; 5(1):11-22. PubMed ID: 8087412.
    Abstract:
    The effect of cortical lesions on the c-fos mRNA expression in adult rat brain was studied using in situ hybridization and Northern blot analysis. It was observed that the single cortical lesion evoked a rapid increase in the content of c-fos mRNA in whole brain. However, when rats received a second and third cortical injury 4 and 8 h after the first one, there was reduced elevation of c-fos mRNA after the second (60%) and third (75%) injuries in comparison with those seen after a single cortical lesion. These results represent the desensitization period during which the induction of c-fos mRNA by repeated cortical lesions was decreased. On the contrary, when animals were treated with a fourth cortical lesion 24 h after the first injury, with recovery for 16 h after the third one, the levels of c-fos mRNA were again elevated to a degree almost comparable to that seen after the single injury alone. The anatomical distribution of c-fos mRNA-expressing cells after cortical lesions revealed a large increase of hybridization to a heterogeneous population of hippocampal neurons including small cells of stratum granulosum in the dentate gyrus and larger cells within hippocampal stratum pyramidale. A dramatic labeling of neurons with c-fos riboprobe in frontoparietal and piriform cortex was also observed but with predominantly localized hybridization to c-fos mRNA on the damaged side of the cortex following the first and second cortical injury. However, hippocampal distribution of c-fos mRNA-containing cells was bilateral as a result of polysynaptic potentials evoked by cortical lesions.
    [Abstract] [Full Text] [Related] [New Search]