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  • Title: The comparative metabolism of zolazepam in rat, dog and monkey.
    Author: Baukema J, Okerholm RA, Glazko AJ.
    Journal: Res Commun Chem Pathol Pharmacol; 1975 Feb; 10(2):227-38. PubMed ID: 808840.
    Abstract:
    The metabolic disposition.of zolazepam, a pyrazolodiazepinone, was studied in male and female Spartan rats, Beagle dogs and Rhesus monkeys. Six principal urinary metabolites were characterized by gas chromatography and combined gas chromatography-mass spectrometry. The major metabolite in male and female rats was produced by N-demethylation and hydroxylation. In addition, female rats, but not the male demethylated zolazepam at the 1-position. Male and female dogs also demethylated zolazepam in the 1-position and hydroxylated in a position other than C-6, producing a metabolite peculiar to the dog. In marked contrast, the major metabolite in the monkey involved demethylation without subsequent hydroxylation.
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