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  • Title: The Fibrel mechanism of action study. A preliminary report.
    Author: Gold MH.
    Journal: J Dermatol Surg Oncol; 1994 Sep; 20(9):586-90. PubMed ID: 8089358.
    Abstract:
    BACKGROUND: Fibrel is a medical implant device that has demonstrated use in the correction of cutaneous depressions from acne scars and wrinkles. OBJECTIVE: Mechanisms of actions have been proposed that have theorized the production of new collagen over time as a result of the Fibrel implant. The present study utilized human volunteers to study the histologic response of Fibrel over time. METHODS: Fibrel was injected into tattoo sites behind the ears of human volunteers; skin biopsies were taken at various time intervals and studied histologically by a clinical pathologist. RESULTS: An overall increase over time was noted with regard to production of collagen and inflammatory response. No change in elastic tissue was found. CONCLUSIONS: Fibrel does promote new collagen synthesis and inflammatory response and thus is useful to correct cutaneous depressions via soft tissue augmentation.
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