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  • Title: Role of transcobalamins I, II, and III in the transfer of vitamin B12 to human bone marrow cells in vitro.
    Author: Wickramasinghe SN, England JM, Saunders JE, Down MC.
    Journal: Acta Haematol; 1975; 54(2):89-94. PubMed ID: 808945.
    Abstract:
    A study of the uptake of transcobalamin-bound 57Co-cyanocobalamin by suspensions of human bone marrow cells has indicated that these cells can take up vitamin B12 from all 3 transcobalamins (I, II, and III). Similar transport processes were involved in the uptake from the 3 transcobalamins; uptake was dependent on the presence of calcium ions, cellular respiration and free sulphydryl groups. These results suggest that contrary to current belief, all 3 transcobalamins play a role in the transfer of vitamin B12 to tissue cells.
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