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  • Title: Effects of copulation on apomorphine-induced erection in rats.
    Author: Sachs BD, Akasofu K, McEldowney SS.
    Journal: Pharmacol Biochem Behav; 1994 Jun; 48(2):423-8. PubMed ID: 8090810.
    Abstract:
    By testing the effects of antecedent copulation on subsequent apomorphine-induced penile erection we sought to test an implicit assumption in the research on drug-induced "spontaneous" erection--namely, that this research provides information relevant to the regulation of erection in copula. In experiment 1, male rats were observed after being injected SC with 0, 15, 30, 60, or 120 micrograms/kg apomorphine (APO); 60 micrograms/kg yielded the maximum probability of erection and yawning. In experiment 2, males were injected with 60 micrograms/kg APO after no exposure to females, after three intromissions, or after copulation to sexual satiety. There was no significant effect of three intromissions, but sexually sated males displayed no erections, the first evidence that copulation affects drug-induced erections. In experiment 3, males had one ejaculation, three intromissions, or no exposure to females immediately before injection with APO (60 micrograms/kg, SC) or ascorbic acid vehicle. APO induced both erection and yawning, but neither behavior was reliably affected by copulation in APO-treated males. Among vehicle-treated males, those having three intromissions or one ejaculation before the test had shorter erection latencies and more erections than males not exposed to females. Thus, a relatively small amount of copulation resulted in a level of erectile response similar to that of APO-treated males. Optimal doses of APO may be no more effective in promoting erection in male rats than are the natural neurochemical sequelae to copulation.
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