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  • Title: A neuronal nucleolar trigger mechanism traceable by a routine staining method.
    Author: Iyengar B.
    Journal: Acta Anat (Basel); 1978; 102(4):374-7. PubMed ID: 80911.
    Abstract:
    In experimental Wilson's disease produced by the intracardiac injection of copper sulphate, it is seen that the glia-neuronal interactions play an important role in the pathogenesis of neural lesions. A "trigger" copper-RNA particle is transferred from the oligodendroglial nucleus to activate the neuronal nucleolus causing a flooding of the neurone with RNA. This trigger particle stains differently with Mason's trichrome, giving a bright red colour. This altered reaction gives an insight into the feedback process for the formation of ribosomal RNA in the neurones. The alteration appears to lead to a block in the repressor activity of the neuronal RNA formation.
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