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  • Title: [Pharmacology of a new cardiotropic drug : (dichloro-2, 3-methoxy 4) phenyl furyl-2-0-(diethylamino-ethyl)-ketone-oxime (ANP 4364)].
    Author: Bessin P, Thuillier J.
    Journal: C R Acad Hebd Seances Acad Sci D; ; 281(5-8):463-6. PubMed ID: 809213.
    Abstract:
    The (dichloro-2,3 methoxy 4) phenyl furyl-2 0-(diethylaminoethyl)-cetone-oxime (ANP 4364) is a powerful coronary vasodilator which lowers the resistance of large coronary arteries and decreases the O2 consumption of the myocardium. The activity of ANP 4364 is similar to digitalis: increase of cardiac flow, bradycardia, redistribution of the blood to peripheral area. These properties demonstrated in dogs have been confirmed in patients with cardiac diseases.
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