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  • Title: Regulation of cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase mRNA levels by L-tri-iodothyronine.
    Author: Royo T, Haro D, Hegardt FG.
    Journal: Biochem J; 1993 Jan 15; 289 ( Pt 2)(Pt 2):557-60. PubMed ID: 8093833.
    Abstract:
    In hypophysectomized and thyroidectomized rats, cytosolic 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase activity, immunoreactive protein and mRNA levels were all considerably decreased. Administration of L-tri-iodothyronine (T3) resulted in a large increase in all three in hypophysectomized rats and in only a 2-fold increase (reaching the values of control rats) in thyroidectomized rats.
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