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  • Title: Priming to heat shock proteins in infants vaccinated against pertussis.
    Author: Del Giudice G, Gervaix A, Costantino P, Wyler CA, Tougne C, de Graeff-Meeder ER, van Embden J, van der Zee R, Nencioni L, Rappuoli R.
    Journal: J Immunol; 1993 Mar 01; 150(5):2025-32. PubMed ID: 8094730.
    Abstract:
    To investigate whether and in which proportion normal individuals experience a priming to microbial heat shock proteins (hsp), the presence of antibodies to two mycobacterial hsp was tested in serum sample from 2- to 4-mo-old children before and at different times after vaccination with the trivalent vaccine against tetanus, diphtheria, and pertussis (DTP). We show that 88.9% of infants vaccinated with DTP developed antibody responses to mycobacterial hsp. Such a response was due to the whole-cell pertussis component of the vaccine, because it was not observed in infants receiving an acellular pertussis vaccine. Antibodies and cells reactive to the mycobacterial 65-kDa hsp were also found in mice immunized with DTP. Interestingly, whole-cell pertussis vaccine-induced anti-hsp antibodies cross-reacted with the Escherichia coli GroEL hsp, and at a some extent with the human 60-kDa hsp, belonging to the same hsp family. These data suggest that priming of the immune system to hsp is a common phenomenon occurring very early in life.
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