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  • Title: The sigma receptor ligand SR 31742A increases neurotensin in the nucleus accumbens but not in the caudate-putamen of the rat.
    Author: Labie C, Keane PE, Soubrié P, Le Fur G.
    Journal: Eur J Pharmacol; 1993 Feb 16; 231(3):465-7. PubMed ID: 8095466.
    Abstract:
    The effects of SR 31742A, a specific sigma site ligand, were investigated on regional neurotensin concentrations in rat brain. Both acute and chronic (21-day) treatment with either SR 31742A (20 mg/kg i.p.) or haloperidol (1 mg/kg i.p.) increased the neurotensin-like immunoreactivity in the nucleus accumbens. In contrast to haloperidol, the administration of SR 31742A failed to increase the concentration of neurotensin-like immunoreactivity in the caudate-putamen. Thus, the effects of SR 31742A appear to be selective for the limbic system.
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