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  • Title: Dynamic studies with 99mTc-HEDP in normal subjects and in patients with bone tumors.
    Author: Citrin DL, Bessent RG, McGinley E, Gordon D.
    Journal: J Nucl Med; 1975 Oct; 16(10):886-90. PubMed ID: 809552.
    Abstract:
    Blood clearance, urinary excretion, and spinal uptake of 99mTc-HEDP have been measured in ten normal control subjects. Blood clearance from 15 min is biexponential. Approximately 70% of the administered activity was excreted in the urine within 6 hr of injection. Spine-to-background ratios rise sequentially with time. Net normal bone uptake rises little after 2 hr and improved visualization of the normal skeleton therafter is due to reduction of blood background activity. In 13 patients with bone tumors, direct measurement of diphosphonate uptake by the tumor-involved and corresponding normal bone showed a continued rise in diphosphonate levels in the tumor-involved bone due to increased metabolic activity.
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