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  • Title: [Duration of effective hypoglycaemic action of glipizide given once daily (author's transl)].
    Author: Azzopardi J, Campbell IW, Clarke BF, Duncan LJ.
    Journal: Med Klin; 1975 Jul 11; 70(28-29):1214-8. PubMed ID: 809650.
    Abstract:
    The clinically effective duration of blood glucose lowering action of a new hypoglycaemic sulphonylurea, glipizide, given in single before breakfast dosage (up to 20 mg) has been studied in 20 apparently insulin-independent diabetics. All, on diet only, had persistent overnight 1-2% glycosuria, fasting glycaemia in excess of 150 mg/100ml, random mid-morning glycaemia of at least 250 mg/100ml and associated clinical symptoms. Eighteen were satisfactorily controlled over the observation period of six months by single daily dosage (mean 10 mg daily); in addition considerable improvement in glucose tolerance occurred. Complementary in-patients indicated that, within the range of dosage studied, there was no therapeutic advantage in taking glipizide twice daily.
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