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  • Title: 6-OHDA-treated weanling rats show normal neuroleptic sensitivity as adults on LHSS.
    Author: Sidhu KS, Stellar JR, Garity D, Bruno JP.
    Journal: Pharmacol Biochem Behav; 1993 Apr; 44(4):901-5. PubMed ID: 8097044.
    Abstract:
    Weanling rats receiving 6-hydroxydopamine (6-OHDA) ICV on postnatal days 15-20 and tested as adults have normal lateral hypothalamic self-stimulation locus of rise (LOR) reward thresholds but significantly lower operant motor/performance (MAX) capacity when compared to vehicle-treated controls using the rate-frequency method. These results are comparable to those previously seen in adult rats treated with 6-OHDA on postnatal day 3. In a second test, day 15-20 6-OHDA treated rats were tested as adults with pimozide (0.125-1.0 mg/kg) and showed LOR shifts ranging from 0.06-0.32 log Hz and MAX shifts of 83-47% of baseline. These results were not significantly different at any dose when compared to day 15-20 vehicle-treated rats. This second result contrasts with the pimozide subsensitivity previously reported in day 3 6-OHDA treated rats and suggests that DA depletions made later in neonatal life may involve different forms of recovery than those seen with earlier dopamine depletions.
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