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  • Title: Treatment of Parkinson's disease with the partial dopamine agonist EMD 49980.
    Author: Bravi D, Davis TL, Mouradian MM, Chase TN.
    Journal: Mov Disord; 1993 Apr; 8(2):195-7. PubMed ID: 8097280.
    Abstract:
    The motor effects of the partial dopamine agonist EMD 49980 were evaluated in parkinsonian patients under controlled conditions. EMD 49980 monotherapy resulted in a mild improvement in parkinsonian symptoms, but when co-administered with levodopa, had no significant effect on dyskinesias or on the antiparkinsonian effect of the dopamine precursor. These results suggest that EMD 49980 exerts a net weak dopamine agonist effect but fails to ameliorate levodopa-induced dyskinesias.
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