These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Centpropazine affinity to cortical noradrenergic receptors and effect on their responsiveness in the rat.
    Author: Dikshit M, Chalecka-Franaszek E, Nalepa I.
    Journal: J Pharm Pharmacol; 1993 Mar; 45(3):228-30. PubMed ID: 8097784.
    Abstract:
    We have studied the in-vitro effect of centpropazine on cerebral cortical noradrenergic receptors measured as the accumulation of second messengers, cyclic AMP and inositol phosphate, stimulated by noradrenaline, and the binding to alpha 1- and beta-adrenoceptors. Centpropazine inhibited inositol phosphate, but not the cyclic AMP accumulation in the cerebral cortical slices of the rat. It moderately antagonized the specific binding of [3H]prazosin, but did not affect the specific binding of the beta-adrenoceptor ligand, [3H]CGP 12177, to cerebral cortical membranes.
    [Abstract] [Full Text] [Related] [New Search]