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  • Title: [The analysis of human DNA fingerprints by the synthetic oligonucleotide probe].
    Author: Lan L, Zhang X, Huo Z, Duan B.
    Journal: Yi Chuan Xue Bao; 1993; 20(1):1-6. PubMed ID: 8099494.
    Abstract:
    In order to test the practical applicability of oligonucleotide fingerprinting we have investigated 50 unrelated individuals, 11 members in two families and one pair of twin using the probe (CAC)5/(GTG)5. Except the monozygotic twins highly variable patterns were demonstrated, even in a family. The probability of chance association between random individuals was calculated as 3.8 x 10(-10). It seems reasonable to conclude that (CAC)5/(GTG)5 fingerprints are completely individual-specific. The results of the pedigree study showed that the inheritance of alleles was in keeping with the Mendelian Law. This method is not so costly and labor-intensive as the conventional Southern blotting. It increases the speed and lessen the complexity of RFLPs study.
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