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  • Title: [The role of monoamin- and acidergic mechanisms of the hippocampus in anxiety states of different origins and their participation in the antiaversive effects of anxiolytics].
    Author: Talalaenko AN, Krivobok GK, Stakhovskiĭ IuV.
    Journal: Fiziol Zh Im I M Sechenova; 1993 Jan; 79(1):99-104. PubMed ID: 8100168.
    Abstract:
    The experiments on rats with tests of avoiding "lighting square" and "threatening situation" and with the chemical stimulation of dorsal and ventral hippocampus with dopamine, 5-HT, GABA and glutamine acid, showed different functional significance of these monoamines and acidergic transmitters agents in the states of anxiety of heteromodal aversive genesis. It seems that the variations in the action spectrum of anxiolytics under study are due to unequal degree of 5-HT and GABA-ergic transmitter mechanisms of dorsal and ventral hippocampus.
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