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  • Title: Hepatic oxygen consumption and cytochrome P450 activity in experimental faecal peritonitis.
    Author: Rasmussen I, Rane A, Haglund U.
    Journal: Eur J Surg; 1993 Apr; 159(4):201-7. PubMed ID: 8102539.
    Abstract:
    OBJECTIVE: To study hepatic oxygen consumption and cytochrome P450 activity in pigs with septic shock induced by faecal peritonitis. DESIGN: Controlled experimental study. ANIMALS: 12 pigs weighing 19-27 kg. INTERVENTION: The animals were divided into a control group (n = 6) and a peritonitis group (n = 6). Peritonitis was induced by intraperitoneal instillation of a standard amount of autologous faeces. The animals were then observed for 300 minutes. Liver biopsy specimens were taken at 0 and 300 minutes. MAIN OUTCOME MEASURES: Hepatic oxygen delivery (DO2) and consumption (VO2). Cytochrome P450 activity was studied by measuring O- and N-demethylation of codeine at 0 and 300 minutes. RESULTS: Hepatic DO2 was reduced, whereas VO2 was increased during sepsis. There were no significant changes in the N- and O-demethylation of codeine. CONCLUSIONS: Hepatic VO2 did increase during sepsis, possibly because of the increased metabolic demand. Cytochrome P450 activity was unaffected by the septic challenge.
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