These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Enhanced anxiolytic effect of zacopride enantiomers in diazepam-withdrawn rats.
    Author: File SE, Andrews N.
    Journal: Eur J Pharmacol; 1993 Jun 11; 237(1):127-30. PubMed ID: 8102974.
    Abstract:
    The effects of a low (0.001 mg/kg) and a high (0.1 mg/kg) dose of the R(+) and S(-) enantiomers of zacopride were investigated in the elevated plus-maze in control-treated and diazepam-withdrawn rats. The rats withdrawn from diazepam were tested 36 h after the last of 28 days of treatment (2 mg/kg per day). The rats withdrawn from diazepam had a significant anxiogenic response, shown by decreases in the percentage of open arm entries and the percentage of time spent on the open arms. The low dose of S(-)-zacopride and both doses of R(+)-zacopride significantly reversed this anxiogenic response. In contrast, in the control-treated rats there were no significant effects on any measure of either isomer at doses of 0.001, 0.1 or 1 mg/kg.
    [Abstract] [Full Text] [Related] [New Search]