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  • Title: Radiation-induced inhibition of RNA synthesis in Tetrahymena pyriformis.
    Author: Ernst SG, Rustad RC, Oleinick NL.
    Journal: Int J Radiat Biol Relat Stud Phys Chem Med; 1975 Jul; 28(1):67-74. PubMed ID: 810444.
    Abstract:
    Radiation-induced disturbances in RNA synthesis were investigated in exponentially growing Tetrahymena. Sub-lethal doses of gamma-radiation lead to a transient, dose-dependent decrease in the rate of total RNA synthesis measured by 3H-uridine incorporation, without an alteration of 3H-uridine uptake by the cells. The rate of 3H-uridine incorporation decreases exponentially with dose. In contrast, the duration of inhibition of RNA synthesis is linearly dependent on dose. Target-theory calculations suggest that the sensitive molecule has a molecular weight of about 2 X 10(7) Daltons.
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