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  • Title: Central alpha 2-adrenoceptor-mediated inhibition of gastric motility in rats.
    Author: Nagata M, Osumi Y.
    Journal: Jpn J Pharmacol; 1993 Jul; 62(3):329-30. PubMed ID: 8105126.
    Abstract:
    We investigated the subtype of alpha-adrenoceptors participating in central noradrenergic inhibition of gastric motility in urethane-anesthetized rats. Noradrenaline at 10 nmole administered intracisternally (i.c.) significantly decreased gastric motility. Yohimbine at 10 nmole, i.c., but not the same dose of prazosin, abolished this noradrenaline-induced decrease in gastric motility. Clonidine at 10 nmole, i.c., but not phenylephrine at 20 nmole, significantly decreased gastric motility. These results suggest that alpha 2-adrenoceptor-mediated mechanisms in the brain stem are involved in noradrenergic inhibitory regulation of gastric motility.
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