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  • Title: Stimulation of ciliary motility mediated by atypical beta-adrenoceptor in canine bronchial epithelium.
    Author: Tamaoki J, Chiyotani A, Sakai N, Konno K.
    Journal: Life Sci; 1993; 53(20):1509-15. PubMed ID: 8105356.
    Abstract:
    The effects of catecholamines on ciliary motility of canine bronchial epithelium was studied by a photoelectric method in vitro. Addition of beta-adrenoceptor agonists increased ciliary beat frequency, a rank order of potency being salbutamol > or = BRL 37344, a selective beta 3-adrenoceptor agonist > norepinephrine. The response to BRL 37344 was relatively resistant to the blockade of beta 1- and beta 2-adrenoceptors but was competitively antagonized by the beta 3-adrenoceptor antagonist cyanopindolol, with the pA2 value being lower than that when salbutamol was used as an agonist. These results suggest that beta 3-adrenoceptors exist in canine bronchial epithelium and that stimulation of this receptor subtype may enhance ciliary motility and, hence, mucociliary transport in the airway.
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