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  • Title: Skeletal muscle mitochondrial myopathy as a cause of exercise intolerance in a horse.
    Author: Valberg SJ, Carlson GP, Cardinet GH, Birks EK, Jones JH, Chomyn A, DiMauro S.
    Journal: Muscle Nerve; 1994 Mar; 17(3):305-12. PubMed ID: 8107707.
    Abstract:
    Although exertional myopathies are commonly recognized in horses, specific etiologies have not been identified. This is the first report in the horse of a deficiency of Complex I respiratory chain enzyme associated with profound exercise intolerance. Physical examination, routine blood tests, endoscopy, and ultrasonograms of the heart and iliac arteries were unremarkable. With slow, incremental exercise (speeds 1.5-7 m/s), the Arabian mare showed a marked lactic acidosis, increased mixed venous PVO2, and little change in oxygen consumption. Muscle biopsies contained large accumulations of mitochondria with bizarre cristae formations. Biochemical analyses revealed a very low activity of the first enzyme complex in the mitochondrial respiratory chain (NADH CoQ reductase). The exercise intolerance and muscle stiffness in this horse were attributed to a profound lactic acidosis resulting from impaired oxidative energy metabolism during exercise.
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