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  • Title: Bloom's syndrome cells GM1492 lack detectable p53 protein but exhibit normal G1 cell-cycle arrest after UV irradiation.
    Author: van Laar T, Steegenga WT, Jochemsen AG, Terleth C, van der Eb AJ.
    Journal: Oncogene; 1994 Mar; 9(3):981-3. PubMed ID: 8108144.
    Abstract:
    The tumor suppressor gene p53 is thought to be a key factor in the onset of G1 cell-cycle arrest following DNA damage. However, here we describe cells derived from a patient with Bloom's syndrome, lacking any detectable p53 protein, that still shows a functional G1 cell-cycle checkpoint after irradiation with UV-C. Comparison with cells from other Bloom's patients showed that the absence of p53 protein is not a specific characteristic of Bloom's syndrome.
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