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  • Title: Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85.
    Author: Kaffman A, Herskowitz I, Tjian R, O'Shea EK.
    Journal: Science; 1994 Feb 25; 263(5150):1153-6. PubMed ID: 8108735.
    Abstract:
    Induction of the yeast gene PHO5 is mediated by the transcription factors PHO2 and PHO4. PHO5 transcription is not detectable in high phosphate; it is thought that the negative regulators PHO80 and PHO85 inactivate PHO2 and PHO4. Here it is reported that PHO80 has homology to yeast cyclins and interacts with PHO85, a p34cdc2/CDC28-related protein kinase. The PHO80-PHO85 complex phosphorylates PHO4; this phosphorylation is correlated with negative regulation of PHO5. These results demonstrate the existence of a cyclin-cdk complex that is used for a regulatory process other than cell-cycle control and identify a physiologically relevant substrate for this complex.
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