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  • Title: In vitro activity of a new carbapenem antibiotic, BO-2727, with potent antipseudomonal activity.
    Author: Nakagawa S, Hashizume T, Matsuda K, Sanada M, Okamoto O, Fukatsu H, Tanaka N.
    Journal: Antimicrob Agents Chemother; 1993 Dec; 37(12):2756-9. PubMed ID: 8109950.
    Abstract:
    BO-2727, a new 1-beta-methyl-carbapenem, was active at concentrations of 6.25 micrograms/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenem-resistant (MICs, > or = 12.5 micrograms/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more active than imipenem and meropenem. BO-2727's antipseudomonal activity and its broad spectrum merit further investigation for clinical use by itself, since it was stable in the presence of renal dehydropeptidase I.
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