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  • Title: [Changes in the ultrastruct of the rat kidney after intoxication with organophosphates (author's transl)].
    Author: Hettwer H.
    Journal: Acta Histochem; 1975; 52(2):165-210. PubMed ID: 811039.
    Abstract:
    The kidneys of female Sprague Dawley rats were examined by electronmicroscopical and histochemical methods after intoxication with O-pinacolyl-methyl-phosphonylfluoride. The same explorations were made with control animals, with animals after hypoxia for 24 h, and starving for 36 h. The epithelial cells of the proximal and distal convoluted tubule cells showed the following changes: In the epithelial cells of the basal labyrinth there was a striking extention. The swelling of the intercompartmental space were discussed in connection with a restricted return of sodium-resorption. Further changes in the epithelial cells of the two nephron-segments after organophosphat-intoxication are the swelling of the mitochondria, the reduction of the cristae up to the total destruction of these mitochondria, the formation of myelin-figures, the swelling of the ER and the GOLGI complex.
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